diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index 797133111..1e7a60595 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -40,6 +40,7 @@ Features:
 - Add ``options`` parameter to ``AudioResampler`` for passing ``libswresample`` options (e.g. ``resampler``, ``filter_size``, ``cutoff``) by :gh-user:`WyattBlue` (:issue:`2262`).
 - Support ``yuv420p10le`` in ``VideoFrame.to_ndarray`` and ``VideoFrame.from_ndarray`` by :gh-user:`WyattBlue` (:issue:`1981`).
 - Add ``at`` parameter to ``Graph.push`` and ``Graph.vpush`` to push a frame to a single buffer source by index, for multi-input filters like ``overlay`` by :gh-user:`WyattBlue`.
+- ``find_best_pix_fmt_of_list`` now returns the loss as a ``PixFmtLoss`` ``enum.IntFlag`` instead of a plain ``int`` by :gh-user:`WyattBlue` (:issue:`2300`).
 
 Fixes:
 
diff --git a/av/codec/__init__.py b/av/codec/__init__.py
index f8d4d75ae..f8f589de8 100644
--- a/av/codec/__init__.py
+++ b/av/codec/__init__.py
@@ -1,6 +1,7 @@
 from .codec import (
     Capabilities,
     Codec,
+    PixFmtLoss,
     Properties,
     codecs_available,
     find_best_pix_fmt_of_list,
@@ -10,6 +11,7 @@
 __all__ = (
     "Capabilities",
     "Codec",
+    "PixFmtLoss",
     "Properties",
     "codecs_available",
     "find_best_pix_fmt_of_list",
diff --git a/av/codec/codec.py b/av/codec/codec.py
index 616980641..edda0c29d 100644
--- a/av/codec/codec.py
+++ b/av/codec/codec.py
@@ -1,4 +1,4 @@
-from enum import Flag, IntEnum
+from enum import Flag, IntEnum, IntFlag
 
 import cython
 from cython.cimports import libav as lib
@@ -54,6 +54,22 @@ class Capabilities(IntEnum):
     encoder_recon_frame = 1 << 22
 
 
+class PixFmtLoss(IntFlag):
+    """Flags describing what is lost when converting between pixel formats.
+
+    Returned by :func:`find_best_pix_fmt_of_list`. Mirrors FFmpeg's
+    ``FF_LOSS_*`` flags.
+    """
+
+    NONE = 0
+    RESOLUTION = 0x0001  # loss due to resolution change
+    DEPTH = 0x0002  # loss due to color depth change
+    COLORSPACE = 0x0004  # loss due to color space conversion
+    ALPHA = 0x0008  # loss of alpha bit
+    COLORQUANT = 0x0010  # loss due to color quantization
+    CHROMA = 0x0020  # loss of chroma (e.g. RGB to gray conversion)
+
+
 class UnknownCodecError(ValueError):
     pass
 
@@ -419,7 +435,7 @@ def find_best_pix_fmt_of_list(pix_fmts, src_pix_fmt, has_alpha=False):
     :param src_pix_fmt: Source pixel format (str or VideoFormat).
     :param bool has_alpha: Whether the source alpha channel is used.
     :return: (best_format, loss)
-    :rtype: (VideoFormat | None, int)
+    :rtype: (VideoFormat | None, PixFmtLoss)
     """
     src: lib.AVPixelFormat
     best: lib.AVPixelFormat
@@ -434,7 +450,7 @@ def find_best_pix_fmt_of_list(pix_fmts, src_pix_fmt, has_alpha=False):
 
     pix_fmts = tuple(pix_fmts)
     if not pix_fmts:
-        return None, 0
+        return None, PixFmtLoss.NONE
 
     if isinstance(src_pix_fmt, VideoFormat):
         src = cython.cast(VideoFormat, src_pix_fmt).pix_fmt
@@ -462,7 +478,7 @@ def find_best_pix_fmt_of_list(pix_fmts, src_pix_fmt, has_alpha=False):
         best = lib.avcodec_find_best_pix_fmt_of_list(
             c_list, src, 1 if has_alpha else 0, cython.address(c_loss)
         )
-        return get_video_format(best, 0, 0), c_loss
+        return get_video_format(best, 0, 0), PixFmtLoss(c_loss)
     finally:
         if c_list != cython.NULL:
             free(c_list)
diff --git a/av/codec/codec.pyi b/av/codec/codec.pyi
index 32c83371e..a9876c4f5 100644
--- a/av/codec/codec.pyi
+++ b/av/codec/codec.pyi
@@ -1,5 +1,5 @@
 from collections.abc import Sequence
-from enum import Flag, IntEnum
+from enum import Flag, IntEnum, IntFlag
 from fractions import Fraction
 from typing import ClassVar, Literal, cast, overload
 
@@ -44,6 +44,15 @@ class Capabilities(IntEnum):
     encoder_flush = cast(int, ...)
     encoder_recon_frame = cast(int, ...)
 
+class PixFmtLoss(IntFlag):
+    NONE = cast(ClassVar[PixFmtLoss], ...)
+    RESOLUTION = cast(ClassVar[PixFmtLoss], ...)
+    DEPTH = cast(ClassVar[PixFmtLoss], ...)
+    COLORSPACE = cast(ClassVar[PixFmtLoss], ...)
+    ALPHA = cast(ClassVar[PixFmtLoss], ...)
+    COLORQUANT = cast(ClassVar[PixFmtLoss], ...)
+    CHROMA = cast(ClassVar[PixFmtLoss], ...)
+
 class UnknownCodecError(ValueError): ...
 
 class Codec:
@@ -117,7 +126,7 @@ def find_best_pix_fmt_of_list(
     pix_fmts: Sequence[PixFmtLike],
     src_pix_fmt: PixFmtLike,
     has_alpha: bool = False,
-) -> tuple[VideoFormat | None, int]:
+) -> tuple[VideoFormat | None, PixFmtLoss]:
     """
     Find the best pixel format to convert to given a source format.
 
@@ -127,10 +136,15 @@ def find_best_pix_fmt_of_list(
     :param src_pix_fmt: Source pixel format (str or VideoFormat).
     :param bool has_alpha: Whether the source alpha channel is used.
     :return: (best_format, loss): best_format is the best matching pixel format from
-        the list, or None if no suitable format was found; loss is Combination of flags informing you what kind of losses will occur.
-    :rtype: (VideoFormat | None, int)
+        the list, or None if no suitable format was found; loss is a combination of
+        :class:`PixFmtLoss` flags informing you what kind of losses will occur.
+    :rtype: (VideoFormat | None, PixFmtLoss)
 
-    Note on loss: it is a bitmask of FFmpeg loss flags describing what kinds of information would be lost converting from src_pix_fmt to best_format (e.g. loss of alpha, chroma, colorspace, resolution, bit depth, etc.). Multiple losses can be present at once, so the value is meant to be interpreted with bitwise & against FFmpeg's FF_LOSS_* constants.
+    Note on loss: it is an :class:`enum.IntFlag` describing what kinds of information
+    would be lost converting from src_pix_fmt to best_format (e.g. loss of alpha,
+    chroma, colorspace, resolution, bit depth, etc.). Multiple losses can be present
+    at once, so the value can be tested with bitwise & against the :class:`PixFmtLoss`
+    members.
     For exact behavior see: libavutil/pixdesc.c/get_pix_fmt_score() in ffmpeg source code.
     """
     ...
diff --git a/docs/api/codec.rst b/docs/api/codec.rst
index 43bb235c2..7b6c261e3 100644
--- a/docs/api/codec.rst
+++ b/docs/api/codec.rst
@@ -43,6 +43,19 @@ Flags
 
     Note that ``ffmpeg -codecs`` prefers the properties versions of ``INTRA_ONLY`` and ``LOSSLESS``.
 
+Pixel Format Selection
+----------------------
+
+.. autofunction:: find_best_pix_fmt_of_list
+
+.. autoclass:: PixFmtLoss
+
+    Wraps FFmpeg's ``FF_LOSS_*`` flags. Returned by
+    :func:`find_best_pix_fmt_of_list` to describe what is lost when converting
+    from the source pixel format to the chosen one. Being an
+    :class:`enum.IntFlag`, members can be combined and tested with bitwise
+    operators.
+
 Contexts
 --------
 
diff --git a/tests/test_codec.py b/tests/test_codec.py
index 17432c926..2f8b95e0b 100644
--- a/tests/test_codec.py
+++ b/tests/test_codec.py
@@ -1,7 +1,7 @@
 import pytest
 
 from av import AudioFormat, Codec, VideoFormat, codecs_available
-from av.codec import find_best_pix_fmt_of_list
+from av.codec import PixFmtLoss, find_best_pix_fmt_of_list
 from av.codec.codec import UnknownCodecError
 
 
@@ -96,6 +96,7 @@ def test_find_best_pix_fmt_of_list_empty() -> None:
     best, loss = find_best_pix_fmt_of_list([], "rgb24")
     assert best is None
     assert loss == 0
+    assert loss is PixFmtLoss.NONE
 
 
 @pytest.mark.parametrize(
@@ -151,3 +152,16 @@ def test_find_best_pix_fmt_of_list_alpha_loss_flagged_when_used() -> None:
     assert best is not None
     assert best.name == "rgb24"
     assert loss != 0
+    assert isinstance(loss, PixFmtLoss)
+    assert loss & PixFmtLoss.ALPHA
+
+
+def test_find_best_pix_fmt_of_list_loss_flags() -> None:
+    # An identical format loses nothing.
+    _, loss = find_best_pix_fmt_of_list(["yuv420p"], "yuv420p")
+    assert loss is PixFmtLoss.NONE
+
+    # Converting color to grayscale drops the chroma planes.
+    _, loss = find_best_pix_fmt_of_list(["gray"], "rgb24")
+    assert isinstance(loss, PixFmtLoss)
+    assert loss & PixFmtLoss.CHROMA