diff --git a/newsfragments/6262.added.md b/newsfragments/6262.added.md
new file mode 100644
index 00000000000..8c1452089dc
--- /dev/null
+++ b/newsfragments/6262.added.md
@@ -0,0 +1 @@
+Add tss api to ffi crate
diff --git a/pyo3-ffi/src/lib.rs b/pyo3-ffi/src/lib.rs
index 7fdf12a0094..77a43cc2cf5 100644
--- a/pyo3-ffi/src/lib.rs
+++ b/pyo3-ffi/src/lib.rs
@@ -483,6 +483,7 @@ pub use self::pymem::*;
 pub use self::pyport::*;
 pub use self::pystate::*;
 pub use self::pystrtod::*;
+pub use self::pythead::*;
 pub use self::pythonrun::*;
 pub use self::pytypedefs::*;
 pub use self::rangeobject::*;
@@ -574,7 +575,7 @@ mod pythonrun;
 // skipped pystrhex.h
 // skipped pystrcmp.h
 mod pystrtod;
-// skipped pythread.h
+mod pythead;
 // skipped pytime.h
 mod pytypedefs;
 mod rangeobject;
diff --git a/pyo3-ffi/src/pythead.rs b/pyo3-ffi/src/pythead.rs
new file mode 100644
index 00000000000..75dfa2eb517
--- /dev/null
+++ b/pyo3-ffi/src/pythead.rs
@@ -0,0 +1,34 @@
+use core::ffi::{c_int, c_void};
+
+#[cfg(Py_LIMITED_API)]
+opaque_struct!(pub Py_tss_t);
+
+#[cfg(not(Py_LIMITED_API))]
+#[repr(C)]
+pub struct Py_tss_t {
+    _is_initialized: c_int,
+    _key: NATIVE_TSS_KEY_T,
+}
+
+#[cfg(not(Py_LIMITED_API))]
+pub const Py_tss_NEEDS_INIT: Py_tss_t = Py_tss_t {
+    _is_initialized: 0,
+    _key: 0,
+};
+
+#[cfg(all(windows, not(Py_LIMITED_API)))]
+type NATIVE_TSS_KEY_T = core::ffi::c_ulong;
+
+#[cfg(all(not(windows), not(Py_LIMITED_API)))]
+type NATIVE_TSS_KEY_T = libc::pthread_key_t;
+
+extern_libpython! {
+    pub fn PyThread_tss_alloc() -> *mut Py_tss_t;
+    pub fn PyThread_tss_free(key: *mut Py_tss_t);
+
+    pub fn PyThread_tss_is_created(key: *mut Py_tss_t) -> c_int;
+    pub fn PyThread_tss_create(key: *mut Py_tss_t) -> c_int;
+    pub fn PyThread_tss_delete(key: *mut Py_tss_t);
+    pub fn PyThread_tss_set(key: *mut Py_tss_t, value: *mut c_void) -> c_int;
+    pub fn PyThread_tss_get(key: *mut Py_tss_t) -> *mut c_void;
+}