diff --git a/docs/en/setup/Plugins.md b/docs/en/setup/Plugins.md
index 0aa38a31..baea2144 100644
--- a/docs/en/setup/Plugins.md
+++ b/docs/en/setup/Plugins.md
@@ -47,6 +47,7 @@ or a limitation of SkyWalking auto-instrumentation (welcome to contribute!)
 | [sanic](https://sanic.readthedocs.io/en/latest) | Python >=3.10 - NOT SUPPORTED YET; Python >=3.7 - ['20.12'];  | `sw_sanic` |
 | [tornado](https://www.tornadoweb.org) | Python >=3.14 - ['6.4']; Python >=3.10 - ['6.0', '6.1'];  | `sw_tornado` |
 | [urllib3](https://urllib3.readthedocs.io/en/latest/) | Python >=3.12 - NOT SUPPORTED YET; Python >=3.10 - ['1.26', '1.25'];  | `sw_urllib3` |
+| [urllib3](https://urllib3.readthedocs.io/en/latest/) | Python >=3.12 - ['2.3', '2.0'];  | `sw_urllib3_v2` |
 | [urllib_request](https://docs.python.org/3/library/urllib.request.html) | Python >=3.7 - ['*'];  | `sw_urllib_request` |
 | [websockets](https://websockets.readthedocs.io) | Python >=3.7 - ['10.3', '10.4'];  | `sw_websockets` |
 ### Notes
@@ -58,6 +59,8 @@ Hug is believed to be abandoned project, use this plugin with a bit more caution
 Instead of Hug, plugin test should move to test actual Falcon.
 - The Neo4j plugin integrates neo4j python driver 5.x.x versions which
 support both Neo4j 5 and 4.4 DBMS.
+- urllib3 1.x plugin. For urllib3 2.x, see sw_urllib3_v2.
+- urllib3 2.x plugin. For urllib3 1.x, see sw_urllib3.
 - The websocket instrumentation only traces client side connection handshake,
 the actual message exchange (send/recv) is not traced since injecting headers to socket message
 body is the only way to propagate the trace context, which requires customization of message structure
diff --git a/skywalking/plugins/sw_urllib3.py b/skywalking/plugins/sw_urllib3.py
index ae57b9c9..56f7f737 100644
--- a/skywalking/plugins/sw_urllib3.py
+++ b/skywalking/plugins/sw_urllib3.py
@@ -23,11 +23,11 @@
 link_vector = ['https://urllib3.readthedocs.io/en/latest/']
 support_matrix = {
     'urllib3': {
-        '>=3.12': [],  # urllib3 2.x removed urllib3.request.RequestMethods, plugin needs adaptation
+        '>=3.12': [],  # urllib3 1.x can't install on 3.12+, see sw_urllib3_v2 for 2.x
         '>=3.10': ['1.26', '1.25'],
     }
 }
-note = """"""
+note = """urllib3 1.x plugin. For urllib3 2.x, see sw_urllib3_v2."""
 
 
 def install():
diff --git a/skywalking/plugins/sw_urllib3_v2.py b/skywalking/plugins/sw_urllib3_v2.py
new file mode 100644
index 00000000..1e8e3e07
--- /dev/null
+++ b/skywalking/plugins/sw_urllib3_v2.py
@@ -0,0 +1,77 @@
+#
+# Licensed to the Apache Software Foundation (ASF) under one or more
+# contributor license agreements.  See the NOTICE file distributed with
+# this work for additional information regarding copyright ownership.
+# The ASF licenses this file to You under the Apache License, Version 2.0
+# (the "License"); you may not use this file except in compliance with
+# the License.  You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+#
+
+from skywalking import Layer, Component, config
+from skywalking.trace.context import get_context, NoopContext
+from skywalking.trace.span import NoopSpan
+from skywalking.trace.tags import TagHttpMethod, TagHttpURL, TagHttpStatusCode
+
+link_vector = ['https://urllib3.readthedocs.io/en/latest/']
+support_matrix = {
+    'urllib3': {
+        '>=3.12': ['2.3', '2.0'],
+    }
+}
+note = """urllib3 2.x plugin. For urllib3 1.x, see sw_urllib3."""
+
+
+def install():
+    from urllib3 import PoolManager
+
+    # urllib3 2.x removed RequestMethods base class;
+    # PoolManager.request is the direct entry point.
+    # Guard: if RequestMethods still exists, this is urllib3 1.x — let sw_urllib3 handle it.
+    try:
+        from urllib3.request import RequestMethods  # noqa: F401
+        return  # urllib3 1.x detected, skip — sw_urllib3 handles it
+    except ImportError:
+        pass  # urllib3 2.x, proceed
+
+    _request = PoolManager.request
+
+    def _sw_request(this: PoolManager, method, url, body=None, fields=None, headers=None, json=None, **urlopen_kw):
+        from skywalking.utils.filter import sw_urlparse
+
+        url_param = sw_urlparse(url)
+
+        span = NoopSpan(NoopContext()) if config.ignore_http_method_check(method) \
+            else get_context().new_exit_span(op=url_param.path or '/', peer=url_param.netloc,
+                                             component=Component.Urllib3)
+
+        with span:
+            carrier = span.inject()
+            span.layer = Layer.Http
+
+            if headers is None:
+                headers = {}
+            else:
+                headers = dict(headers)
+            for item in carrier:
+                headers[item.key] = item.val
+
+            span.tag(TagHttpMethod(method.upper()))
+            span.tag(TagHttpURL(url_param.geturl()))
+
+            res = _request(this, method, url, body=body, fields=fields, headers=headers, json=json, **urlopen_kw)
+
+            span.tag(TagHttpStatusCode(res.status))
+            if res.status >= 400:
+                span.error_occurred = True
+
+            return res
+
+    PoolManager.request = _sw_request
diff --git a/tests/plugin/http/sw_urllib3/test_urllib3.py b/tests/plugin/http/sw_urllib3/test_urllib3.py
index 082cd33b..2fff31df 100644
--- a/tests/plugin/http/sw_urllib3/test_urllib3.py
+++ b/tests/plugin/http/sw_urllib3/test_urllib3.py
@@ -19,10 +19,15 @@
 import pytest
 import requests
 
-from skywalking.plugins.sw_urllib3 import support_matrix
+from skywalking.plugins.sw_urllib3 import support_matrix as v1_matrix
+from skywalking.plugins.sw_urllib3_v2 import support_matrix as v2_matrix
 from tests.orchestrator import get_test_vector
 from tests.plugin.base import TestPluginBase
 
+# Merge v1 and v2 test vectors — get_test_vector returns versions for the current Python
+_versions = (get_test_vector(lib_name='urllib3', support_matrix=v1_matrix)
+             + get_test_vector(lib_name='urllib3', support_matrix=v2_matrix))
+
 
 @pytest.fixture
 def prepare():
@@ -31,6 +36,6 @@ def prepare():
 
 
 class TestPlugin(TestPluginBase):
-    @pytest.mark.parametrize('version', get_test_vector(lib_name='urllib3', support_matrix=support_matrix))
+    @pytest.mark.parametrize('version', _versions)
     def test_plugin(self, docker_compose, version):
         self.validate()