diff --git a/python/packages/core/agent_framework/_agents.py b/python/packages/core/agent_framework/_agents.py
index 379601fa256..3e293b15fd8 100644
--- a/python/packages/core/agent_framework/_agents.py
+++ b/python/packages/core/agent_framework/_agents.py
@@ -2,6 +2,7 @@
 
 from __future__ import annotations
 
+import keyword
 import logging
 import re
 import sys
@@ -248,6 +249,10 @@ def _sanitize_agent_name(agent_name: str | None) -> str | None:
     if sanitized and sanitized[0].isdigit():
         sanitized = f"_{sanitized}"
 
+    # Suffix with underscore if the sanitized name is a reserved Python keyword
+    if keyword.iskeyword(sanitized):
+        sanitized = f"{sanitized}_"
+
     return sanitized
 
 
diff --git a/python/packages/core/tests/core/test_agents.py b/python/packages/core/tests/core/test_agents.py
index c3e132656aa..b9c0b633249 100644
--- a/python/packages/core/tests/core/test_agents.py
+++ b/python/packages/core/tests/core/test_agents.py
@@ -3458,6 +3458,16 @@ def test_sanitize_agent_name_replaces_invalid_chars():
     assert "!" not in result  # type: ignore[operator]  # pyrefly: ignore[not-iterable]  # ty: ignore[unsupported-operator]
 
 
+def test_sanitize_agent_name_handles_python_keywords():
+    """Test _sanitize_agent_name appends trailing underscore for Python keywords."""
+    assert _sanitize_agent_name("for") == "for_"
+    assert _sanitize_agent_name("def") == "def_"
+    assert _sanitize_agent_name("class") == "class_"
+    assert _sanitize_agent_name("return") == "return_"
+    assert _sanitize_agent_name("import") == "import_"
+    assert _sanitize_agent_name("pass") == "pass_"
+
+
 # endregion