diff --git a/.changelog/5399.fixed b/.changelog/5399.fixed
new file mode 100644
index 00000000000..21a38f5b099
--- /dev/null
+++ b/.changelog/5399.fixed
@@ -0,0 +1 @@
+`opentelemetry-api`: Prevent in-place mutation of `Context` via inherited `dict` methods
diff --git a/opentelemetry-api/src/opentelemetry/context/context.py b/opentelemetry-api/src/opentelemetry/context/context.py
index c8d87a422dd..984bf424d84 100644
--- a/opentelemetry-api/src/opentelemetry/context/context.py
+++ b/opentelemetry-api/src/opentelemetry/context/context.py
@@ -11,6 +11,27 @@ class Context(dict[str, object]):
     def __setitem__(self, key: str, value: object) -> None:
         raise ValueError
 
+    def __delitem__(self, key: str) -> None:
+        raise ValueError
+
+    def setdefault(self, key: str, default: object = None) -> object:
+        raise ValueError
+
+    def pop(self, key: str, *args: object) -> object:
+        raise ValueError
+
+    def popitem(self) -> tuple[str, object]:
+        raise ValueError
+
+    def clear(self) -> None:
+        raise ValueError
+
+    def update(self, *args: object, **kwargs: object) -> None:
+        raise ValueError
+
+    def __ior__(self, other: object) -> Context:
+        raise ValueError
+
 
 class _RuntimeContext(ABC):
     """The RuntimeContext interface provides a wrapper for the different
diff --git a/opentelemetry-api/tests/context/test_context.py b/opentelemetry-api/tests/context/test_context.py
index ce5327d8680..10b32de363d 100644
--- a/opentelemetry-api/tests/context/test_context.py
+++ b/opentelemetry-api/tests/context/test_context.py
@@ -54,9 +54,23 @@ def test_set_value(self):
         self.assertEqual(None, context.get_value("a"))
 
     def test_context_is_immutable(self):
+        ctx = context.get_current()
         with self.assertRaises(ValueError):
-            # ensure a context
-            context.get_current()["test"] = "cant-change-immutable"
+            ctx["test"] = "cant-change-immutable"
+        with self.assertRaises(ValueError):
+            del ctx["test"]
+        with self.assertRaises(ValueError):
+            ctx.pop("test")
+        with self.assertRaises(ValueError):
+            ctx.popitem()
+        with self.assertRaises(ValueError):
+            ctx.clear()
+        with self.assertRaises(ValueError):
+            ctx.update({"test": "cant-change-immutable"})
+        with self.assertRaises(ValueError):
+            ctx.setdefault("test", "cant-change-immutable")
+        with self.assertRaises(ValueError):
+            ctx |= {"test": "cant-change-immutable"}
 
     def test_set_current(self):
         context.attach(context.set_value("a", "yyy"))