diff --git a/lms/djangoapps/mfe_config_api/docs/decisions/0001-mfe-config-api.rst b/lms/djangoapps/mfe_config_api/docs/decisions/0001-mfe-config-api.rst
index 8e298991186d..9760f698ec19 100644
--- a/lms/djangoapps/mfe_config_api/docs/decisions/0001-mfe-config-api.rst
+++ b/lms/djangoapps/mfe_config_api/docs/decisions/0001-mfe-config-api.rst
@@ -16,7 +16,11 @@ Decision
 ********
 
 - A lightweight API will be created that returns the mfe configuration variables from the site configuration or django settings. `PR Discussion about django settings`_
-- The API will be enabled or disabled using the setting ``ENABLE_MFE_CONFIG_API``.
+- The API will always be available.  It was originally gated behind an
+  ``ENABLE_MFE_CONFIG_API`` toggle that defaulted to ``False``; that toggle was
+  removed by the `DEPR ticket for ENABLE_MFE_CONFIG_API`_ because the API only exposes
+  non-sensitive frontend configuration and returns nothing that an operator has
+  not explicitly configured.
 - The API will take the mfe configuration in the ``MFE_CONFIG`` keyset in the site configuration (admin > site configuration > your domain) or in django settings.
 - This API allows to consult the configurations by specific MFE. Making a request like ``/api/mfe_config/v1?mfe=mymfe`` will return the configuration defined in ``MFE_CONFIG_OVERRIDES["mymfe"]`` merged with the ``MFE_CONFIG`` configuration.
 - The API will have a mechanism to cache the response with ``MFE_CONFIG_API_CACHE_TIMEOUT`` variable.
@@ -70,3 +74,5 @@ References
 .. _Issue MFE runtime configuration in frontend-wg: https://github.com/openedx/frontend-wg/issues/103
 
 .. _PR Discussion about django settings: https://github.com/openedx/edx-platform/pull/30473#discussion_r916263245
+
+.. _DEPR ticket for ENABLE_MFE_CONFIG_API: https://github.com/openedx/openedx-platform/issues/38959
diff --git a/lms/djangoapps/mfe_config_api/tests/test_views.py b/lms/djangoapps/mfe_config_api/tests/test_views.py
index 8b508544acc8..2d0020d58b10 100644
--- a/lms/djangoapps/mfe_config_api/tests/test_views.py
+++ b/lms/djangoapps/mfe_config_api/tests/test_views.py
@@ -182,19 +182,6 @@ def test_get_mfe_config_with_queryparam_from_django_settings(self):
         expected = default_legacy_config | settings.MFE_CONFIG | settings.MFE_CONFIG_OVERRIDES["mymfe"]
         self.assertEqual(response.json(), expected)  # noqa: PT009
 
-    @patch("lms.djangoapps.mfe_config_api.views.configuration_helpers")
-    @override_settings(ENABLE_MFE_CONFIG_API=False)
-    def test_404_get_mfe_config(self, configuration_helpers_mock):
-        """Test the 404 not found response from get mfe config.
-
-        Expected result:
-        - The get_value method of configuration_helpers is not called.
-        - The status of the response of the request is a HTTP_404_NOT_FOUND.
-        """
-        response = self.client.get(self.mfe_config_api_url)
-        configuration_helpers_mock.get_value.assert_not_called()
-        self.assertEqual(response.status_code, status.HTTP_404_NOT_FOUND)  # noqa: PT009
-
     @patch("lms.djangoapps.mfe_config_api.views.configuration_helpers")
     def test_get_mfe_config_for_catalog(self, configuration_helpers_mock):
         """Test the mfe config by explicitly using catalog mfe as an example.
@@ -488,12 +475,6 @@ def setUp(self):
         cache.clear()
         return super().setUp()
 
-    @override_settings(ENABLE_MFE_CONFIG_API=False)
-    def test_404_when_disabled(self):
-        """API returns 404 when ENABLE_MFE_CONFIG_API is False."""
-        response = self.client.get(self.url)
-        self.assertEqual(response.status_code, status.HTTP_404_NOT_FOUND)  # noqa: PT009
-
     @patch("lms.djangoapps.mfe_config_api.views.configuration_helpers")
     def test_site_level_keys_translated(self, configuration_helpers_mock):
         """Keys that map to RequiredSiteConfig/OptionalSiteConfig appear at the top level in camelCase."""
diff --git a/lms/djangoapps/mfe_config_api/views.py b/lms/djangoapps/mfe_config_api/views.py
index 647751730619..eb98b224ed8e 100644
--- a/lms/djangoapps/mfe_config_api/views.py
+++ b/lms/djangoapps/mfe_config_api/views.py
@@ -6,12 +6,11 @@
 
 import edx_api_doc_tools as apidocs
 from django.conf import settings
-from django.http import HttpResponseNotFound, JsonResponse
+from django.http import JsonResponse
 from django.utils.decorators import method_decorator
 from django.views.decorators.cache import cache_page
 from help_tokens.core import HelpUrlExpert
 from rest_framework import status
-from rest_framework.exceptions import NotFound
 from rest_framework.permissions import AllowAny
 from rest_framework.response import Response
 from rest_framework.views import APIView
@@ -299,9 +298,6 @@ def get(self, request):
         ```
         """
 
-        if not settings.ENABLE_MFE_CONFIG_API:
-            return HttpResponseNotFound()
-
         mfe_name = (
             str(request.query_params.get("mfe"))
             if request.query_params.get("mfe")
@@ -438,9 +434,6 @@ def get(self, request):
         }
         ```
         """
-        if not settings.ENABLE_MFE_CONFIG_API:
-            raise NotFound()
-
         # Legacy translation (removable once MFE_CONFIG is deprecated).
         site_config = translate_legacy_mfe_config()
 
diff --git a/lms/envs/common.py b/lms/envs/common.py
index e8a185c1d49c..431a83328263 100644
--- a/lms/envs/common.py
+++ b/lms/envs/common.py
@@ -3066,18 +3066,6 @@
 FINANCIAL_ASSISTANCE_APPLICATION_STATUS_URL = "/core/api/financial_assistance_application/status/"
 CREATE_FINANCIAL_ASSISTANCE_APPLICATION_URL = '/core/api/financial_assistance_applications'
 
-# .. toggle_name: ENABLE_MFE_CONFIG_API
-# .. toggle_implementation: DjangoSetting
-# .. toggle_default: False
-# .. toggle_description: Set to True to enable MFE Config API. This is disabled by
-#   default.
-# .. toggle_use_cases: open_edx
-# .. toggle_creation_date: 2022-05-20
-# .. toggle_target_removal_date: None
-# .. toggle_warnings: None
-# .. toggle_tickets: None
-ENABLE_MFE_CONFIG_API = False
-
 # .. setting_name: MFE_CONFIG
 # .. setting_implementation: DjangoSetting
 # .. setting_default: {}
diff --git a/lms/envs/mock.yml b/lms/envs/mock.yml
index 47edb551cc16..3c52f27e0209 100644
--- a/lms/envs/mock.yml
+++ b/lms/envs/mock.yml
@@ -449,7 +449,6 @@ ENABLE_AUTHN_RESET_PASSWORD_HIBP_POLICY: true
 ENABLE_COMPREHENSIVE_THEMING: true
 ENABLE_COPPA_COMPLIANCE: true
 ENABLE_DYNAMIC_REGISTRATION_FIELDS: true
-ENABLE_MFE_CONFIG_API: true
 ENTERPRISE_ADMIN_PORTAL_BASE_URL: hello
 ENTERPRISE_ADMIN_PORTAL_HOSTNAME: hello
 ENTERPRISE_ALL_SERVICE_USERNAMES:
diff --git a/lms/envs/test.py b/lms/envs/test.py
index d9f529e86938..392acc992302 100644
--- a/lms/envs/test.py
+++ b/lms/envs/test.py
@@ -400,7 +400,6 @@
 CORS_ORIGIN_WHITELIST = ['https://sandbox.edx.org']
 
 ################## MFE API ####################
-ENABLE_MFE_CONFIG_API = True
 MFE_CONFIG = {
     "BASE_URL": "https://name_of_mfe.example.com",
     "LANGUAGE_PREFERENCE_COOKIE_NAME": "example-language-preference",