diff --git a/changelog/15067.bugfix.rst b/changelog/15067.bugfix.rst
new file mode 100644
index 00000000000..21880ca68c5
--- /dev/null
+++ b/changelog/15067.bugfix.rst
@@ -0,0 +1,3 @@
+Fixture finalizers registered with ``request.addfinalizer()`` now run even if
+fixture setup is interrupted after registration, including by
+``KeyboardInterrupt`` or an exception from a ``pytest_fixture_setup`` hook.
diff --git a/src/_pytest/fixtures.py b/src/_pytest/fixtures.py
index 7656fca2f5b..c394272a198 100644
--- a/src/_pytest/fixtures.py
+++ b/src/_pytest/fixtures.py
@@ -1203,9 +1203,8 @@ def addfinalizer(self, finalizer: Callable[[], object]) -> None:
         self._finalizers.append(finalizer)
 
     def finish(self, request: SubRequest) -> None:
-        if self.cached_result is None:
-            # Already finished. It is assumed that finalizers cannot be added in
-            # this state.
+        # Setup may have failed before caching a result, but still added finalizers.
+        if self.cached_result is None and not self._finalizers:
             return
 
         exceptions: list[BaseException] = []
diff --git a/testing/python/fixtures.py b/testing/python/fixtures.py
index 8e779a93d76..26a84a45c19 100644
--- a/testing/python/fixtures.py
+++ b/testing/python/fixtures.py
@@ -1091,6 +1091,60 @@ def test_finalizer_ran():
         reprec = pytester.inline_run("-s")
         reprec.assertoutcome(failed=1, passed=1)
 
+    def test_request_addfinalizer_interrupted_setup(self, pytester: Pytester) -> None:
+        pytester.makepyfile(
+            """
+            from pathlib import Path
+            import pytest
+
+            @pytest.fixture
+            def resource(request):
+                request.addfinalizer(
+                    lambda: Path("finalizer-ran").write_text("ran", encoding="utf-8")
+                )
+                raise KeyboardInterrupt
+
+            def test_setup(resource):
+                pass
+            """
+        )
+
+        result = pytester.runpytest_subprocess("-q")
+        assert result.ret == ExitCode.INTERRUPTED
+        assert (pytester.path / "finalizer-ran").read_text(encoding="utf-8") == "ran"
+
+    def test_request_addfinalizer_interrupted_setup_hook(
+        self, pytester: Pytester
+    ) -> None:
+        pytester.makeconftest(
+            """
+            from pathlib import Path
+
+            def pytest_fixture_setup(fixturedef, request):
+                if fixturedef.argname == "resource":
+                    request.addfinalizer(
+                        lambda: Path("finalizer-ran").write_text("ran", encoding="utf-8")
+                    )
+                    raise KeyboardInterrupt
+            """
+        )
+        pytester.makepyfile(
+            """
+            import pytest
+
+            @pytest.fixture
+            def resource():
+                pass
+
+            def test_setup(resource):
+                pass
+            """
+        )
+
+        result = pytester.runpytest_subprocess("-q")
+        assert result.ret == ExitCode.INTERRUPTED
+        assert (pytester.path / "finalizer-ran").read_text(encoding="utf-8") == "ran"
+
     def test_request_addfinalizer_failing_setup_module(
         self, pytester: Pytester
     ) -> None: